A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

Amyloid deposits, neurofibrillary tangles, and neuronal cell death in selectively vulnerable brain regions are the chief hallmarks in Alzheimer's (AD) brains. Glycogen synthase kinase-3 (GSK-3) is one of the key kinases required for AD-type abnormal hyperphosphorylation of tau, which is believe...

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Bibliographic Details
Main Authors: L. Serenó, M. Coma, M. Rodríguez, P. Sánchez-Ferrer, M.B. Sánchez, I. Gich, J.M. Agulló, M. Pérez, J. Avila, C. Guardia-Laguarta, J. Clarimón, A. Lleó, T. Gómez-Isla
Format: Article
Language:English
Published: Elsevier 2009-09-01
Series:Neurobiology of Disease
Subjects:
Tau
Amyloid
Neuronal cell death
GSK-3
Transgenic mice
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001284

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http://www.sciencedirect.com/science/article/pii/S0969996109001284

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