Time-Resolved Transposon Insertion Sequencing Reveals Genome-Wide Fitness Dynamics during Infection

Time-Resolved Transposon Insertion Sequencing Reveals Genome-Wide Fitness Dynamics during Infection

Transposon insertion sequencing (TIS) is a powerful high-throughput genetic technique that is transforming functional genomics in prokaryotes, because it enables genome-wide mapping of the determinants of fitness. However, current approaches for analyzing TIS data assume that selective pressures are...

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Bibliographic Details
Main Authors: Guanhua Yang, Gabriel Billings, Troy P. Hubbard, Joseph S. Park, Ka Yin Leung, Qin Liu, Brigid M. Davis, Yuanxing Zhang, Qiyao Wang, Matthew K. Waldor, Eric J. Rubin
Format: Article
Language:English
Published: American Society for Microbiology 2017-10-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/5/e01581-17

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http://mbio.asm.org/cgi/content/full/8/5/e01581-17

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