ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-β1–42

ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-β1–42

Amyloid-β1–42 (Aβ1–42) is crucial to Alzheimer disease (AD) pathogenesis but the conformation of the toxic Aβ species remains uncertain. AD risk is increased by apolipoprotein E4 (apoE4) and decreased by apoE2 compared with the apoE3 isoform, but whether inheritance of apoE4 represents a gain of neg...

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Bibliographic Details
Main Authors: Barbara L. Trommer, Chirag Shah, Sung Hwan Yun, Georgi Gamkrelidze, Emily S. Pasternak, W. Blaine Stine, Arlene Manelli, Patrick Sullivan, Joseph F. Pasternak, Mary Jo LaDu
Format: Article
Language:English
Published: Elsevier 2005-02-01
Series:Neurobiology of Disease
Subjects:
ApoE
Amyloid-β
Long-term potentiation (LTP)
Dentate gyrus
Alzheimer disease
ApoE transgenic mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001986

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http://www.sciencedirect.com/science/article/pii/S0969996104001986

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