Ethyl pyruvate protects against sepsis-associated encephalopathy through inhibiting the NLRP3 inflammasome

Ethyl pyruvate protects against sepsis-associated encephalopathy through inhibiting the NLRP3 inflammasome

Abstract Background With the advance of antibiotics and life support therapy, the mortality of sepsis has been decreasing in recent years. However, the incidence of sepsis-associated encephalopathy (SAE), a common complication of sepsis, is still high. There are few effective therapies to treat clin...

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Bibliographic Details
Main Authors: Xiaoli Zhong, Lingli Xie, Xiaolong Yang, Fang Liang, Yanliang Yang, Jianbin Tong, Yanjun Zhong, Kai Zhao, Yiting Tang, Chuang Yuan
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Medicine
Subjects:
Sepsis-associated encephalopathy
Ethyl pyruvate
NLRP3 inflammasome
Innate immunity
Sepsis
Online Access:http://link.springer.com/article/10.1186/s10020-020-00181-3

Internet

http://link.springer.com/article/10.1186/s10020-020-00181-3

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