Indirect Radioiodination of DARPin G3 Using N-succinimidyl-<i>Para</i>-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging

Indirect Radioiodination of DARPin G3 Using N-succinimidyl-<i>Para</i>-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging

Radionuclide molecular imaging of human epidermal growth factor receptor 2 (HER2) in breast and gastroesophageal cancer might be used to stratify patients for HER2-targeted therapy as well as monitor treatment response and disease progression. Designed ankyrin repeat proteins (DARPins) are small eng...

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Bibliographic Details
Main Authors: Anzhelika Vorobyeva, Alexey Schulga, Sara S. Rinne, Tyran Günther, Anna Orlova, Sergey Deyev, Vladimir Tolmachev
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
DARPin
HER2
imaging
radionuclide
iodine
radioiodination
Online Access:https://www.mdpi.com/1422-0067/20/12/3047

Internet

https://www.mdpi.com/1422-0067/20/12/3047

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