Synaptic Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders

Synaptic Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders

Tuberous sclerosis complex (TSC) is a rare, multi-system genetic disease with serious neurological and mental symptoms, including autism. Mutations in the <i>TSC1</i>/<i>TSC2</i> genes lead to the overactivation of mTOR signalling, which is also linked to nonsyndromic autism....

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Bibliographic Details
Main Authors: Grzegorz A. Czapski, Lidia Babiec, Henryk Jęśko, Magdalena Gąssowska-Dobrowolska, Magdalena Cieślik, Marta Matuszewska, Małgorzata Frontczak-Baniewicz, Karolina Zajdel, Agata Adamczyk
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
tuberous sclerosis complex
synaptic dysfunction
autism
animal model
Online Access:https://www.mdpi.com/1422-0067/22/18/10058

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https://www.mdpi.com/1422-0067/22/18/10058

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