HIV-1 Vpr activates the G<sub>2 </sub>checkpoint through manipulation of the ubiquitin proteasome system

HIV-1 Vpr activates the G<sub>2 </sub>checkpoint through manipulation of the ubiquitin proteasome system

<p>Abstract</p> <p>HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G<sub>2 </sub>and induction of apoptosis. In the present study, we investigate the role of the ub...

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Bibliographic Details
Main Authors: Argañaraz Enrique R, Monteiro-Filho Carlos MR, Ardon Orly, Zimmerman Erik S, DeHart Jason L, Planelles Vicente
Format: Article
Language:English
Published: BMC 2007-06-01
Series:Virology Journal
Online Access:http://www.virologyj.com/content/4/1/57

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http://www.virologyj.com/content/4/1/57

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