Synthesis of N-Substituted 5-Iodouracils as Antimicrobial and Anticancer Agents

Synthesis of N-Substituted 5-Iodouracils as Antimicrobial and Anticancer Agents

This study reports the synthesis of some substituted 5-iodouracils and their bioactivities. Alkylation of 5-iodouracils gave predominately N1-substituted-(R)-5-iodouracil compounds 7a-d (R = n-C4H9, s-C4H9, CH2C6H11, CH2C6H5) together with N1,N3-disubstituted (R) analogs 8a-b (R = n-C4H9, CH2C6H11)....

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Bibliographic Details
Main Authors: Virapong Prachayasittikul, Somsak Ruchirawat, Apilak Worachartcheewan, Ratchanok Pingaew, Nirun Sornsongkhram, Supaluk Prachayasittikul
Format: Article
Language:English
Published: MDPI AG 2009-07-01
Series:Molecules
Subjects:
5-iodouracil analogs
N-alkylation
antibacterial
antimalarial
anticancer activities
Online Access:http://www.mdpi.com/1420-3049/14/8/2768/

Internet

http://www.mdpi.com/1420-3049/14/8/2768/

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