Targeted Next-Generation Sequencing Combined With Circulating-Free DNA Deciphers Spatial Heterogeneity of Resected Multifocal Hepatocellular Carcinoma

Targeted Next-Generation Sequencing Combined With Circulating-Free DNA Deciphers Spatial Heterogeneity of Resected Multifocal Hepatocellular Carcinoma

BackgroundHepatocellular carcinoma (HCC) has a high risk of recurrence after surgical resection, particularly among patients with multifocal HCC. Genomic heterogeneity contributes to the early recurrence. Few studies focus on targeted next-generation sequencing (tNGS) to depict mutational footprints...

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Bibliographic Details
Main Authors: Jianzhen Lin, Songhui Zhao, Dongxu Wang, Yang Song, Yue Che, Xu Yang, Jinzhu Mao, Fucun Xie, Junyu Long, Yi Bai, Xiaobo Yang, Lei Zhang, Jin Bian, Xin Lu, Xinting Sang, Jie Pan, Kai Wang, Haitao Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
hepatocellular carcinoma
heterogeneity
circulating-free DNA
somatic mutation
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.673248/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.673248/full

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