Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or <i>BRCA1</i> Alteration

Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or <i>BRCA1</i> Alteration

The identification of biomarker-driven targeted therapies for patients with triple negative breast cancer (TNBC) remains a major clinical challenge, due to a lack of specific targets. Here, we show that cyclin E, a major regulator of G1 to S transition, is deregulated in TNBC and is associated with...

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Bibliographic Details
Main Authors: Xian Chen, Dong Yang, Jason P. W. Carey, Cansu Karakas, Constance Albarracin, Aysegul A. Sahin, Banu K. Arun, Merih Guray Durak, Mi Li, Mehrnoosh Kohansal, Tuyen N. Bui, Min Jin Ha, Kelly K. Hunt, Khandan Keyomarsi
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
cyclin E
low molecular weight cyclin E (LMWE) PARP
Wee1 kinase
DNA replication stress
BRCA
Online Access:https://www.mdpi.com/2072-6694/13/7/1656

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https://www.mdpi.com/2072-6694/13/7/1656

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