Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.

<h4>Background</h4>Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these associations is unclear. We sought to assess the caus...

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Main Authors: Søren D Østergaard, Shubhabrata Mukherjee, Stephen J Sharp, Petroula Proitsi, Luca A Lotta, Felix Day, John R B Perry, Kevin L Boehme, Stefan Walter, John S Kauwe, Laura E Gibbons, Alzheimer’s Disease Genetics Consortium, GERAD1 Consortium, EPIC-InterAct Consortium, Eric B Larson, John F Powell, Claudia Langenberg, Paul K Crane, Nicholas J Wareham, Robert A Scott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-06-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1001841

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https://doi.org/10.1371/journal.pmed.1001841

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