Effect of extension of the heparin binding pocket on the structure, stability, and cell proliferation activity of the human acidic fibroblast growth factor

Effect of extension of the heparin binding pocket on the structure, stability, and cell proliferation activity of the human acidic fibroblast growth factor

Acidic human fibroblast growth factor (hFGF1) plays a key role in cell growth and proliferation. Activation of the cell surface FGF receptor is believed to involve the glycosaminoglycan, heparin. However, the exact role of heparin is a subject of considerable debate. In this context, in this study,...

Full description

Bibliographic Details
Main Authors: Julie Eberle Davis, Ravi Kumar Gundampati, Srinivas Jayanthi, Joshua Anderson, Abigail Pickhardt, Bhanu prasanth Koppolu, David A. Zaharoff, Thallapuranam Krishnaswamy Suresh Kumar
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Biochemistry and Biophysics Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580817301954

Internet

http://www.sciencedirect.com/science/article/pii/S2405580817301954

Similar Items