Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator

Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator

Amyloid <i>&#946;</i>42 (A&#946;42), a causative agent of Alzheimer&#8217;s disease (AD), is derived extracellularly from A<i>&#946;</i> precursor protein (APP) following the latter&#8217;s cleavage by <i>&#946;</i>-secretase, but not &...

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Bibliographic Details
Main Authors: Kazuma Murakami, Mayuko Yoshimura, Shota Nakagawa, Toshiaki Kume, Takayuki Kondo, Haruhisa Inoue, Kazuhiro Irie
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
alzheimer’s disease
amyloid <i>β</i>
bryostatin-1
ece1
ips
nelav
neurotoxicity
oligomer
protein kinase c
<i>α</i>-secretase
Online Access:https://www.mdpi.com/1422-0067/21/4/1179

Internet

https://www.mdpi.com/1422-0067/21/4/1179

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