Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been studied and proposed as CAIs. In this study w...

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Bibliographic Details
Main Authors: Claudia Melis, Rita Meleddu, Andrea Angeli, Simona Distinto, Giulia Bianco, Clemente Capasso, Filippo Cottiglia, Rossella Angius, Claudiu T. Supuran, Elias Maccioni
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Antitumour agents
carbonic anhydrase inhibitors
isatin hybrid molecules
Online Access:http://dx.doi.org/10.1080/14756366.2016.1235042

Internet

http://dx.doi.org/10.1080/14756366.2016.1235042

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