Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38
The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphorylation, thereby modulating ATF2’s sensitivity to...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19582-3 |
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doaj-8e3a384b4b1a49a98424465168b5b1a62021-05-11T07:59:56ZengNature Publishing GroupNature Communications2041-17232020-11-0111111510.1038/s41467-020-19582-3Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38Klára Kirsch0András Zeke1Orsolya Tőke2Péter Sok3Ashish Sethi4Anna Sebő5Ganesan Senthil Kumar6Péter Egri7Ádám L. Póti8Paul Gooley9Wolfgang Peti10Isabel Bento11Anita Alexa12Attila Reményi13Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural SciencesBiomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural SciencesLaboratory for NMR Spectroscopy, Research Center for Natural SciencesBiomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural SciencesDepartment of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of MelbourneBiomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural SciencesDepartment of Chemistry and Biochemistry, University of ArizonaBiomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural SciencesBiomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural SciencesDepartment of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of MelbourneDepartment of Chemistry and Biochemistry, University of ArizonaEuropean Molecular Biology LaboratoryBiomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural SciencesBiomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural SciencesThe ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphorylation, thereby modulating ATF2’s sensitivity to the JNK and p38 pathways.https://doi.org/10.1038/s41467-020-19582-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Klára Kirsch András Zeke Orsolya Tőke Péter Sok Ashish Sethi Anna Sebő Ganesan Senthil Kumar Péter Egri Ádám L. Póti Paul Gooley Wolfgang Peti Isabel Bento Anita Alexa Attila Reményi |
| spellingShingle |
Klára Kirsch András Zeke Orsolya Tőke Péter Sok Ashish Sethi Anna Sebő Ganesan Senthil Kumar Péter Egri Ádám L. Póti Paul Gooley Wolfgang Peti Isabel Bento Anita Alexa Attila Reményi Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38 Nature Communications |
| author_facet |
Klára Kirsch András Zeke Orsolya Tőke Péter Sok Ashish Sethi Anna Sebő Ganesan Senthil Kumar Péter Egri Ádám L. Póti Paul Gooley Wolfgang Peti Isabel Bento Anita Alexa Attila Reményi |
| author_sort |
Klára Kirsch |
| title |
Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38 |
| title_short |
Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38 |
| title_full |
Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38 |
| title_fullStr |
Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38 |
| title_full_unstemmed |
Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38 |
| title_sort |
co-regulation of the transcription controlling atf2 phosphoswitch by jnk and p38 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-11-01 |
| description |
The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphorylation, thereby modulating ATF2’s sensitivity to the JNK and p38 pathways. |
| url |
https://doi.org/10.1038/s41467-020-19582-3 |
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