TP53 isoform junction reads based analysis in malignant and normal contexts

Abstract TP53 is one of the most frequently altered genes in cancer; it can be inactivated by a number of different mechanisms. NM_000546.6 (ENST00000269305.9) is by far the predominant TP53 isoform, however a few other alternative isoforms have been described to be expressed at much lower levels. T...

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Bibliographic Details
Main Authors: Suleyman Vural, Lun-Ching Chang, Laura M. Yee, Dmitriy Sonkin
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96700-1