Curcumin Regulates the r(CGG)exp RNA Hairpin Structure and Ameliorate Defects in Fragile X-Associated Tremor Ataxia Syndrome

Curcumin Regulates the r(CGG)exp RNA Hairpin Structure and Ameliorate Defects in Fragile X-Associated Tremor Ataxia Syndrome

Fragile X-associated tremor ataxia syndrome is an untreatable neurological and neuromuscular disorder caused by unstable expansion of 55–200 CGG nucleotide repeats in 5′ UTR of Fragile X intellectual disability 1 (FMR1) gene. The expansion of CGG repeats in the FMR1 mRNA elicits neuronal cell toxici...

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Bibliographic Details
Main Authors: Arun Kumar Verma, Eshan Khan, Subodh Kumar Mishra, Amit Mishra, Nicolas Charlet-Berguerand, Amit Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Neuroscience
Subjects:
FXTAS
therapeutics
trinucleotide
CGG repeat
RAN translation
splicing defects
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00295/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00295/full

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