Reducing Animal Use with a Biotelemetry-Enhanced Murine Model of Sepsis

Abstract Animal models of sepsis exhibit considerable variability in the temporal development of the physiologic response, which reduces the power of studies, particularly if interventions are tested at arbitrary time points. We developed a biotelemetry-based model of cecal ligation and puncture (CL...

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Bibliographic Details
Main Authors: Anthony Lewis, Brian Zuckerbraun, John Griepentrog, Xianghong Zhang, Matthew Rosengart
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05497-5