Spleen-derived interleukin-10 downregulates the severity of high-fat diet-induced non-alcoholic fatty pancreas disease.

Spleen-derived interleukin-10 downregulates the severity of high-fat diet-induced non-alcoholic fatty pancreas disease.

Obesity is associated with systemic low-grade inflammation and is a risk factor for non-alcoholic fatty pancreas disease (NAFPD), but the molecular mechanisms of these associations are not clear. Interleukin (IL)-10, a potent anti-inflammatory cytokine, is released during acute pancreatitis and is k...

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Bibliographic Details
Main Authors: Koro Gotoh, Megumi Inoue, Kentaro Shiraishi, Takayuki Masaki, Seiichi Chiba, Kimihiko Mitsutomi, Takanobu Shimasaki, Hisae Ando, Kansuke Fujiwara, Isao Katsuragi, Tetsuya Kakuma, Masataka Seike, Toshiie Sakata, Hironobu Yoshimatsu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23285260/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23285260/?tool=EBI

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