Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins

Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in iron metabolism. IRPs...

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Bibliographic Details
Main Authors: Manik C. Ghosh, De-Liang Zhang, Tracey A. Rouault
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Neurobiology of Disease
Subjects:
Iron
Iron regulatory protein
Polycythemia
Pulmonary hypertension
Anemia
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000613

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http://www.sciencedirect.com/science/article/pii/S0969996115000613

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