Impact of trichostatin A and sodium valproate treatment on post-stroke neurogenesis and behavioral outcomes in immature mice

Impact of trichostatin A and sodium valproate treatment on post-stroke neurogenesis and behavioral outcomes in immature mice

Stroke in the neonatal brain frequently results in neurologic impairments including cognitive disability. We investigated the effect of long-term sodium valproate (valproate) and Trichostatin A (TSA) treatment upon post-stroke neurogenesis in the dentate gyrus (DG) of stroke-injured immature mice....

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Bibliographic Details
Main Authors: Shanu eGeorge, Shilpa D Kadam, Natasha D Irving, Geoffrey J Markowitz, Saba eRaja, Anthony eKwan, YuShan eTu, Huigen eChen, Charles eRohde, Dani R Smith, Anne Marie Comi
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Anticonvulsants
Histone Deacetylase Inhibitors
behavioral outcomes
valproate
Trichostatin A
Hippocampal neurogenesis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00123/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00123/full

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