The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning.

The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning.

RASopathies are a family of related syndromes caused by mutations in regulators of the RAS/Extracellular Regulated Kinase 1/2 (ERK1/2) signaling cascade that often result in neurological deficits. RASopathy mutations in upstream regulatory components, such as NF1, PTPN11/SHP2, and RAS have been well...

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Bibliographic Details
Main Authors: Michael C Holter, Lauren T Hewitt, Stephanie V Koebele, Jessica M Judd, Lei Xing, Heather A Bimonte-Nelson, Cheryl D Conrad, Toshiyuki Araki, Benjamin G Neel, William D Snider, Jason M Newbern
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008108

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https://doi.org/10.1371/journal.pgen.1008108

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