Enhanced production of bovine chymosin by autophagy deficiency in the filamentous fungus Aspergillus oryzae.

Aspergillus oryzae has been utilized as a host for heterologous protein production because of its high protein secretory capacity and food-safety properties. However, A. oryzae often produces lower-than-expected yields of target heterologous proteins due to various underlying mechanisms, including d...

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Bibliographic Details
Main Authors: Jaewoo Yoon, Takashi Kikuma, Jun-ichi Maruyama, Katsuhiko Kitamoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3639164?pdf=render