Pharmacological or genetic orexin 1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex

Pharmacological or genetic orexin 1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex

The orexin/hypocretin neuropeptides are produced by a cluster of neurons within the lateral posterior hypothalamus and participate in neuronal regulation by activating their receptors (OX1 and OX2 receptors). The orexin system projects widely through the brain and functions as an interface between...

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Bibliographic Details
Main Authors: Leah eAluisio, Ian eFraser, Tamara eBerdyyeva, Volha eTryputsen, Brock Thomas Shireman, James eShoblock, Tim eLovenberg, Christine eDugovic, Pascal eBonaventure
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Neuroscience
Subjects:
Glutamate
Cortex
biosensor
orexin
MK-801
orexin 1 receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00107/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00107/full

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