Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis

Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis

Abstract Background Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. Mutations are commonly found in the signaling regulating the PI3K/Akt pathway, leading to oncogenic cell proliferation and survival. Key transcription factors that are negat...

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Bibliographic Details
Main Authors: Miao Lu, Daniel Hartmann, Rickmer Braren, Aayush Gupta, Baocai Wang, Yang Wang, Carolin Mogler, Zhangjun Cheng, Thomas Wirth, Helmut Friess, Jörg Kleeff, Norbert Hüser, Yoshiaki Sunami
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Cancer
Subjects:
HCC
FOXO
Akt
ROS
DNA damage
NADPH
Online Access:http://link.springer.com/article/10.1186/s12885-019-6110-6

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http://link.springer.com/article/10.1186/s12885-019-6110-6

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