A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.

A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.

K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary for tobacco carcinogen-driven lung tumorigenesis and are sufficient to cause lung adenocarcinomas in transgenic mice. Because these mutations...

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Bibliographic Details
Main Authors: Courtney A Granville, Regan M Memmott, Andria Balogh, Jacopo Mariotti, Shigeru Kawabata, Wei Han, Jaclyn Lopiccolo, Jason Foley, David J Liewehr, Seth M Steinberg, Daniel H Fowler, M Christine Hollander, Phillip A Dennis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2659439?pdf=render

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http://europepmc.org/articles/PMC2659439?pdf=render

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