The Plasma Kallikrein–Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice

The Plasma Kallikrein–Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice

The kallikrein–kinin system (KKS) consists of two serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high-molecular-weight kininogen (HK). Upon activation of the KKS, HK is cleaved to release bradykinin. Although the KKS is activated in humans and animals with inflammatory...

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Bibliographic Details
Main Authors: Bo Wang, Aizhen Yang, Zhenzhen Zhao, Chao He, Yuanyuan Liu, Robert W. Colman, Jihong Dai, Yi Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
kallikrein–kinin system
colitis
inflammation
neutrophil
cytokine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00021/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00021/full

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