Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome

Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome

Neurogenesis impairment is considered a major determinant of the intellectual disability that characterizes Down syndrome (DS), a genetic condition caused by triplication of chromosome 21. Previous evidence obtained in the Ts65Dn mouse model of DS showed that the triplicated gene APP (amyloid precur...

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Bibliographic Details
Main Authors: Fiorenza Stagni, Alessandra Raspanti, Andrea Giacomini, Sandra Guidi, Marco Emili, Elisabetta Ciani, Alessandro Giuliani, Andrea Bighinati, Laura Calzà, Jacopo Magistretti, Renata Bartesaghi
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Neurobiology of Disease
Subjects:
Down syndrome
Neonatal pharmacotherapy
APP
Gamma-secretase
Hippocampal development
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117300591

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