Emerging Three-Dimensional Hepatic Models in Relation to Traditional Two-Dimensional In Vitro Assays for Evaluating Drug Metabolism and Hepatoxicity

Emerging Three-Dimensional Hepatic Models in Relation to Traditional Two-Dimensional In Vitro Assays for Evaluating Drug Metabolism and Hepatoxicity

A vital aspect of preclinical drug development involves assessing hepatic metabolism and toxicity. These screenings are typically conducted utilizing in vitro assays and in vivo animal models; however, recent advancements in tissue engineering offer a hybrid approach to augment current protocols. Th...

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Bibliographic Details
Main Authors: Erin Milner, Michael Ainsworth, Matthew McDonough, Benjamin Stevens, Johannah Buehrer, Richard Delzell, Cameron Wilson, Jason Barnhill
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Medicine in Drug Discovery
Subjects:
3D Bioprinting
Hepatotoxicity
Printed Organ
Organ-on-a-chip
Spheroid
Liver Toxicity Assays
Online Access:http://www.sciencedirect.com/science/article/pii/S2590098620300476

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http://www.sciencedirect.com/science/article/pii/S2590098620300476

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