Intranasal dopamine reduces in vivo [123I]FP-CIT binding to striatal dopamine transporter: correlation with behavioral changes and evidence for Pavlovian conditioned dopamine response

Intranasal dopamine reduces in vivo [123I]FP-CIT binding to striatal dopamine transporter: correlation with behavioral changes and evidence for Pavlovian conditioned dopamine response

Purpose: Dopamine (DA), which does not cross the blood-brain barrier, has central and behavioral effects when administered via the nasal route. Neither the mechanisms of central action of intranasal dopamine (IN-DA), nor its mechanisms of diffusion and transport into the brain are well understood. W...

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Bibliographic Details
Main Authors: Maria A de Souza Silva, C. eMattern, C.I. eDecheva, Joseph P. Huston, A. eSadile, M. eBeu, H.W. eMüller, Susanne eNikolaus
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Dopamine
placebo
intranasal administration
Pavlovian conditioning
dopamine transporter
small animal SPECT
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00080/full

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http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00080/full

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