Exploring Kinase Inhibition Properties of 9<i>H</i>-pyrimido[5,4-<i>b</i>]- and [4,5-<i>b</i>]indol-4-amine Derivatives

Exploring Kinase Inhibition Properties of 9<i>H</i>-pyrimido[5,4-<i>b</i>]- and [4,5-<i>b</i>]indol-4-amine Derivatives

<b> </b>We previously highlighted the interest in 6,5,6-fused tricyclic analogues of 4-aminoquinazolines as kinase inhibitors in the micromolar to the nanomolar range of IC<sub>50</sub> values. For the generation of chemical libraries, the formamide-mediated cyclization of th...

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Bibliographic Details
Main Authors:	Yvonnick Loidreau, Carole Dubouilh-Benard, Marie-Renée Nourrisson, Nadège Loaëc, Laurent Meijer, Thierry Besson, Pascal Marchand
Format:	Article
Language:	English
Published:	MDPI AG 2020-05-01
Series:	Pharmaceuticals
Subjects:	microwave-assisted chemistry protein kinases CK1 DYRK1A CDK5 GSK-3
Online Access:	https://www.mdpi.com/1424-8247/13/5/89

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