Exploring Kinase Inhibition Properties of 9<i>H</i>-pyrimido[5,4-<i>b</i>]- and [4,5-<i>b</i>]indol-4-amine Derivatives

Exploring Kinase Inhibition Properties of 9<i>H</i>-pyrimido[5,4-<i>b</i>]- and [4,5-<i>b</i>]indol-4-amine Derivatives

<b> </b>We previously highlighted the interest in 6,5,6-fused tricyclic analogues of 4-aminoquinazolines as kinase inhibitors in the micromolar to the nanomolar range of IC<sub>50</sub> values. For the generation of chemical libraries, the formamide-mediated cyclization of th...

Full description

Bibliographic Details
Main Authors: Yvonnick Loidreau, Carole Dubouilh-Benard, Marie-Renée Nourrisson, Nadège Loaëc, Laurent Meijer, Thierry Besson, Pascal Marchand
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceuticals
Subjects:
microwave-assisted chemistry
protein kinases
CK1
DYRK1A
CDK5
GSK-3
Online Access:https://www.mdpi.com/1424-8247/13/5/89

Internet

https://www.mdpi.com/1424-8247/13/5/89

Similar Items