Role of the CXCR4-LASP1 Axis in the Stabilization of Snail1 in Triple-Negative Breast Cancer

Role of the CXCR4-LASP1 Axis in the Stabilization of Snail1 in Triple-Negative Breast Cancer

The CXCL12-CXCR4 axis plays a vital role in many steps of breast cancer metastasis, but the molecular mechanisms have not been fully elucidated. We previously reported that activation of CXCR4 by CXCL12 promotes the nuclear localization of LASP1 (LIM and SH3 protein 1). The nuclear LASP1 then intera...

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Bibliographic Details
Main Authors: Boopathi Subramaniyan, Sangita Sridharan, Cory M. Howard, Augustus M.C. Tilley, Tupa Basuroy, Ivana de la Serna, Elke Butt, Dayanidhi Raman
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
CXCR4
LASP1
Akt
Snail1 stability
A20
GSK-3β
Online Access:https://www.mdpi.com/2072-6694/12/9/2372

Internet

https://www.mdpi.com/2072-6694/12/9/2372

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