Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling.

Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling.

BACKGROUND:Mutation of Wnt signal antagonists Apc or Axin activates beta-catenin signaling in many cancers including the majority of human colorectal adenocarcinomas. The phenotype of apc or axin mutation in the fruit fly Drosophila melanogaster is strikingly similar to that caused by mutation in th...

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Main Authors: Jianhui Guo, Tolga Cagatay, Guangjin Zhou, Chih-Chiang Chan, Shelby Blythe, Kaye Suyama, Li Zheng, Kaifeng Pan, Chiping Qian, Richard Hamelin, Stephen N Thibodeau, Peter S Klein, Keith A Wharton, Wanguo Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2776356?pdf=render

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http://europepmc.org/articles/PMC2776356?pdf=render

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