Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology

Abstract Background Prior studies in C. elegans demonstrated that the expression of aggregation-prone polyglutamine proteins in muscle wall cells compromised the folding of co-expressed temperature-sensitive proteins, prompting interest in whether the accumulation of a misfolded protein in pathologi...

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Bibliographic Details
Main Authors: Michael C. Pace, Guilian Xu, Susan Fromholt, John Howard, Benoit I. Giasson, Jada Lewis, David R. Borchelt
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Molecular Neurodegeneration
Subjects:
Proteostasis
Protein misfolding
Tau
α-Synuclein
SOD1
Proteinopathy
Online Access:http://link.springer.com/article/10.1186/s13024-018-0253-9

Internet

http://link.springer.com/article/10.1186/s13024-018-0253-9

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