Brucella melitensis UGPase inhibits the activation of NF-κB by modulating the ubiquitination of NEMO

Brucella melitensis UGPase inhibits the activation of NF-κB by modulating the ubiquitination of NEMO

Abstract Background UTP-glucose-1-phosphoryl transferase (UGPase) catalyzes the synthesis of UDP-glucose, which is essential for generating the glycogen needed for the synthesis of bacterial lipopolysaccharide (LPS) and capsular polysaccharide, which play important roles in bacterial virulence. Howe...

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Bibliographic Details
Main Authors: Yucheng Zhou, Zhaoyang Bu, Jing Qian, Yuening Cheng, Lianjiang Qiao, Sen Yang, Shipeng Cheng, Xinglong Wang, Linzhu Ren, Yanling Yang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Veterinary Research
Subjects:
Brucella melitensis
UTP-glucose-1-phosphate uridylyltransferase (UGPase)
Nuclear factor-kappa enhancer-binding protein (NF-κB)
Ubiquitination
Online Access:https://doi.org/10.1186/s12917-021-02993-9

Internet

https://doi.org/10.1186/s12917-021-02993-9

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