Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells

Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells

Summary: During inflammation, recruited monocytes can differentiate either into macrophages or dendritic cells (DCs); however, little is known about the environmental factors that determine this cell fate decision. Low extracellular pH is a hallmark of a variety of inflammatory processes and solid t...

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Bibliographic Details
Main Authors: Fernando Erra Díaz, Valeria Ochoa, Antonela Merlotti, Ezequiel Dantas, Ignacio Mazzitelli, Virginia Gonzalez Polo, Juan Sabatté, Sebastián Amigorena, Elodie Segura, Jorge Geffner
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
Monocytes
dendritic cells
differentiation
acidosis
low pH
metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305623

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720305623

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