MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer’s Disease (AD)-Novel and Unique Pathological Features

MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer’s Disease (AD)-Novel and Unique Pathological Features

Of the approximately ~2.65 × 103 mature microRNAs (miRNAs) so far identified in Homo sapiens, only a surprisingly small but select subset—about 35–40—are highly abundant in the human central nervous system (CNS). This fact alone underscores the extremely high selection pressure for the human CNS to...

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Bibliographic Details
Main Authors: Yuhai Zhao, Aileen I. Pogue, Walter J. Lukiw
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:International Journal of Molecular Sciences
Subjects:
Aβ42 peptide
age-related macular degeneration (AMD)
amyloid clearance
heterogeneity of the disease process
inflammation
innate-immune response
microRNA (miRNA)
miRNA-7
miRNA-9
miRNA-34a
miRNA-125b
miRNA-146a
miRNA-155
normal aging
prion disease
sporadic AD
Online Access:http://www.mdpi.com/1422-0067/16/12/26223

Internet

http://www.mdpi.com/1422-0067/16/12/26223

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