Longitudinal Changes in the Motor Learning-Related Brain Activation Response in Presymptomatic Huntington's Disease.

Neurocognitive decline, including deficits in motor learning, occurs in the presymptomatic phase of Huntington's disease (HD) and precedes the onset of motor symptoms. Findings from recent neuroimaging studies have linked these deficits to alterations in fronto-striatal and fronto-parietal brai...

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Bibliographic Details
Main Authors: Florian Holtbernd, Chris C Tang, Andrew Feigin, Vijay Dhawan, Maria Felice Ghilardi, Jane S Paulsen, Mark Guttman, David Eidelberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4871440?pdf=render