Gallic Acid Ameliorated Impaired Lipid Homeostasis in a Mouse Model of High-Fat Diet—and Streptozotocin-Induced NAFLD and Diabetes through Improvement of β-oxidation and Ketogenesis

Gallic Acid Ameliorated Impaired Lipid Homeostasis in a Mouse Model of High-Fat Diet—and Streptozotocin-Induced NAFLD and Diabetes through Improvement of β-oxidation and Ketogenesis

Gallic acid (GA) is a simple polyphenol found in food and traditional Chinese medicine. Here, we determined the effects of GA administration in a combined mouse model of high-fat diet (HFD)-induced obesity and low-dose streptozotocin (STZ)-induced hyperglycemia, which mimics the concurrent non-alcoh...

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Bibliographic Details
Main Authors: Jung Chao, Hao-Yuan Cheng, Ming-Ling Chang, Shyh-Shyun Huang, Jiunn-Wang Liao, Yung-Chi Cheng, Wen-Huang Peng, Li-Heng Pao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
gallic acid
non-alcoholic fatty liver disease
metabolomics
diabetes
β-oxidation
ketogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.606759/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.606759/full

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