Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening

Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening

Abstract Background Rhoptry protein 18 (ROP18) is a key virulence factor of Toxoplasma gondii. The host’s immune responses mediated by immune-related GTPases (IRGs) could be blocked by ROP18’s kinase activity. ROP18 also interacts with various substrates, such as activating transcription factor 6 be...

Full description

Bibliographic Details
Main Authors: Kun Yin, Guihua Zhao, Chao Xu, Xiao Qiu, Biwei Wen, Hui Sun, Gongzhen Liu, Ye Liu, Qingsong Zhao, Qingkuan Wei, Bingcheng Huang, Ge Yan, Jianping Cao
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Parasites & Vectors
Subjects:
Virtual screening
Pharmacophore model
Competitive inhibitors
ROP18
Toxoplasma gondii
Online Access:http://link.springer.com/article/10.1186/s13071-019-3341-y

Internet

http://link.springer.com/article/10.1186/s13071-019-3341-y

Similar Items