Down regulation of T cell receptor expression in COPD pulmonary CD8 cells.

CD8 cells may contribute towards an autoimmune process in COPD. Down regulation of T cell receptor (TCR) signalling molecules occurs in autoimmune diseases with consequent T cell dysfunction. We hypothesise that TCR signalling is abnormal in COPD pulmonary CD8 cells. Micro-array gene expression anal...

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Bibliographic Details
Main Authors: Seamus Grundy, Jonathan Plumb, Simon Lea, Manminder Kaur, David Ray, Dave Singh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3747211?pdf=render