Heterologous Boost Following Mycobacterium bovis BCG Reduces the Late Persistent, Rather Than the Early Stage of Intranasal Tuberculosis Challenge Infection

Heterologous Boost Following Mycobacterium bovis BCG Reduces the Late Persistent, Rather Than the Early Stage of Intranasal Tuberculosis Challenge Infection

Adults are the leading population affected by tuberculosis (TB) epidemic and death. Developing an effective vaccine against adult TB is urgently needed. Mycobacterium bovis Bacillus Calmette-Guerin (BCG) prime-heterologous boost strategy has been explored extensively to protect adults against primar...

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Bibliographic Details
Main Authors: Yaqi Wu, Ming Cai, Jilei Ma, Xindong Teng, Maopeng Tian, Eman Borham Mohamed Borham Bassuoney, Xionglin Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
BCG
heterologous boost
memory T cells
early stage of tuberculosis
late persistent tuberculosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02439/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02439/full

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