A Polyclonal Immune Function Assay Allows Dose-Dependent Characterization of Immunosuppressive Drug Effects but Has Limited Clinical Utility for Predicting Infection on an Individual Basis

A Polyclonal Immune Function Assay Allows Dose-Dependent Characterization of Immunosuppressive Drug Effects but Has Limited Clinical Utility for Predicting Infection on an Individual Basis

Dosage of immunosuppressive drugs after transplantation critically determines rejection and infection episodes. In this study, a global immune function assay was characterized among controls, dialysis-patients, and transplant-recipients to evaluate its utility for pharmacodynamic monitoring of immun...

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Bibliographic Details
Main Authors: Stefanie Marx, Claudia Adam, Janine Mihm, Michael Weyrich, Urban Sester, Martina Sester
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
immunomonitoring
transplantation
immunosuppression
infection
pharmacodynamics
pharmacokinetics
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00916/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00916/full

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