Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage

Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage

Objective: Murine-specific muricholic acids (MCAs) are reported to protect against obesity and associated metabolic disorders. However, the response of mice with genetic depletion of MCA to an obesogenic diet has not been evaluated. We used Cyp2c-deficient (Cyp2c−/−) mice, which lack MCAs and thus h...

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Bibliographic Details
Main Authors: Antwi-Boasiako Oteng, Sei Higuchi, Alexander S. Banks, Rebecca A. Haeusler
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
Bile acid
Muricholic acid
Obesity
Lipid absorption
Glucose homeostasis
Liver fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001733

Internet

http://www.sciencedirect.com/science/article/pii/S2212877821001733

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