Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

Abstract Background Genome-wide association studies have reported more than 100 risk loci for rheumatoid arthritis (RA). These loci are shown to be enriched in immune cell-specific enhancers, but the analysis so far has excluded stromal cells, such as synovial fibroblasts (FLS), despite their crucia...

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Bibliographic Details
Main Authors: Xiangyu Ge, Mojca Frank-Bertoncelj, Kerstin Klein, Amanda McGovern, Tadeja Kuret, Miranda Houtman, Blaž Burja, Raphael Micheroli, Chenfu Shi, Miriam Marks, Andrew Filer, Christopher D. Buckley, Gisela Orozco, Oliver Distler, Andrew P. Morris, Paul Martin, Stephen Eyre, Caroline Ospelt
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Genome Biology
Subjects:
Functional genomics
Stromal cells
Rheumatoid arthritis
Fibroblast-like synoviocytes
Online Access:https://doi.org/10.1186/s13059-021-02460-6

Internet

https://doi.org/10.1186/s13059-021-02460-6

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