The Loop of the TPR1 Subdomain of Phi29 DNA Polymerase Plays a Pivotal Role in Primer-Terminus Stabilization at the Polymerization Active Site

The Loop of the TPR1 Subdomain of Phi29 DNA Polymerase Plays a Pivotal Role in Primer-Terminus Stabilization at the Polymerization Active Site

Bacteriophage Phi29 DNA polymerase belongs to the protein-primed subgroup of family B DNA polymerases that use a terminal protein (TP) as a primer to initiate genome replication. The resolution of the crystallographic structure showed that it consists of an N-terminal domain with the exonuclease act...

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Bibliographic Details
Main Authors: Alicia del Prado, Eugenia Santos, José M. Lázaro, Margarita Salas, Miguel de Vega
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Biomolecules
Subjects:
dna polymerase
replication
protein-priming
terminal protein
Online Access:https://www.mdpi.com/2218-273X/9/11/648

Internet

https://www.mdpi.com/2218-273X/9/11/648

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