CaV1.3 L-Type Calcium Channels Increase the Vulnerability of Substantia Nigra Dopaminergic Neurons in MPTP Mouse Model of Parkinson’s Disease

CaV1.3 L-Type Calcium Channels Increase the Vulnerability of Substantia Nigra Dopaminergic Neurons in MPTP Mouse Model of Parkinson’s Disease

Mechanisms underlying the selective vulnerability of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) over those in the ventral tegmental area (VTA) to degeneration in Parkinson’s disease (PD) remain poorly understood. DA neurons of SNpc and VTA are autonomous pacemakers but pa...

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Bibliographic Details
Main Authors: Aditi Verma, Vijayalakshmi Ravindranath
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
neurodegeneration
SNpc
MPTP
CaV1.342A
gene expression
alternative splicing
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00382/full

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https://www.frontiersin.org/article/10.3389/fnagi.2019.00382/full

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