A new selective, and sensitive method for the determination of lixivaptan, a vasopressin 2 (V2)-receptor antagonist, in mouse plasma and its application in a pharmacokinetic study

A new selective, and sensitive method for the determination of lixivaptan, a vasopressin 2 (V2)-receptor antagonist, in mouse plasma and its application in a pharmacokinetic study

A new, selective and sensitive HPLC method for the determination of lixivaptan, an oral selective vasopressin 2 (V2)-receptor antagonist, was investigated and validated. A Waters symmetry C18 column was used as a stationary phase in isocratic elution mode using a mobile phase composed of KH2PO4 (100...

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Bibliographic Details
Main Authors: Alrabiah Haitham, Abunassif Mohammed, Attia Sabry, Mostafa Gamal Abdel-Hafiz
Format: Article
Language:English
Published: De Gruyter 2018-07-01
Series:Open Chemistry
Subjects:
lixivaptan
hplc/uv
mouse plasma
pharmacokinetic
Online Access:https://doi.org/10.1515/chem-2018-0063

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