Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR

Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR

Repeat-associated non-ATG translation of dipeptide repeat proteins (DPRs) contributes to disease manifestation in FTD/ALS associated with the hexanucleotide repeat expansion of the C9ORF72 gene. Here the authors show that a transgenic mouse line expressing poly-PR28 in neurons displays some signs of...

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Bibliographic Details
Main Authors: Zongbing Hao, Liu Liu, Zhouteng Tao, Rui Wang, Haigang Ren, Hongyang Sun, Zixuan Lin, Zhixiong Zhang, Chenchen Mu, Jiawei Zhou, Guanghui Wang
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10956-w

Internet

https://doi.org/10.1038/s41467-019-10956-w

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